Immunology MCQs

Immunology MCQs

Answer these 100+ Immunology MCQs and see how sharp is your knowledge of Immunology. Scroll down and let's start!

1: __________ is not a cardinal sign characteristic of inflammation.

A.   Impaired use

B.   Redness

C.   Pain

D.   Heat E

E.   Swelling

2: Activated cd8 t cells become __________.

A.   Helper T cells

B.   NK cells

C.   Cytotoxic T cells

D.   B cells

3: Antibodies are ___ proteins while antigens are ___ proteins.

A.   Bacterial; self-produced

B.   Self-produced; foreign

C.   Self-produced; also self-produced

D.   Cancer; bacterial

E.   Viral; self-produced

A.   Specificity, antigen

B.   Antigen, immune cell

C.   Antigenic determinants, different

D.   T cells, highest antigenicity

5: Cell-mediated immunity is to t cells as antibody-mediated immunity is to ___________.

A.   B cells

B.   NK cells

C.   TH cells

D.   T cells

6: Clonal selection of b cells ________.

A.   Occurs during fetal development

B.   Results in the formation of plasma cells

C.   Cannot occur in the presence of antigens

D.   Only occurs in the secondary immune response

7: Complement fixation cannot lead to __________.

A.   Enhanced inflammation

B.   Opsonization

C.   Endogenous pyrexia

D.   Bacterial phagocytosis

8: Exogenous antigens are processed for immune recognition by ________ cells.

A.   Macrophage

B.   All nucleated

C.   Dendritic

D.   Helper T

E.   Dendritic and macrophage

9: Histamine is released from the _____ cells

A.   Mast cells

B.   Th helper cells

C.   Tc helper cells

D.   B cells

10: Immunological memory accounts for _____.

A.   An antigen can provoke production of high levels of specific antibodies

B.   Be unable to differentiate and mature T cells

C.   The ancient observation that someone who had recovered from the plague could safely care for those newly diseased.

D.   Recombination of the segments of the receptor DNA that make up the functional receptor genes of differentiated B cells

11: Membrane attack complex (mac) kills by ________.

A.   Has a lag period while B cells proliferate and differentiate into plasma cells

B.   Phagocytosis

C.   Disrupting the selectively permeability of a bacteria's plasma membrane

D.   Can kill cancer cells before the adaptive immune system is activated

12: Most often, antigens are composed of __________.

A.   MHC proteins

B.   Phagolysosome

C.   Macrophages

D.   Glycoproteins

13: Proteins on the surface of phagocytes called ________ aid in the detection of pathogen molecules.

A.   NOD proteins

B.   Lectins and C3 protein

C.   Lectins

D.   TLRs

E.   Both TLRs and NOD proteins

14: T cells of the immune system include _____.

A.   CD4, CD8, and plasma cells

B.   Cytotoxic and helper cells

C.   Plasma, antigen-presenting, and memory cells

D.   Lymphocytes, macrophages, and dendritic cells

15: Memory t cells can be up to __________ old.

A.   Weeks

B.   Days

C.   Decades

D.   Years

E.   Months

16: This variable region gives an antibody ______ for an _______.

A.   Specificity, antigen

B.   T cells, highest antigenicity

C.   Helper T cells

D.   Somatic hypermutation

17: When antibodies bind antigens, the clumping of antigens results from _____.

A.   The antibody having at least two binding regions

B.   Denaturation of the antibodies

C.   Bonds between class I and class II MHC molecules

D.   Disulfide bridges between the antigens

18: Antibody functions include all of the following except ________.

A.   Binding and inactivating chemical toxins released by bacteria or other microorganisms

B.   Cross-linking cell-bound antigens on red blood cells when blood types are properly matched

C.   Linking soluble antigens together so that they fall out of solution

D.   Targeting foreign cells so that complement proteins can cause cellular lysis

19: B cells respond to the initial antigen challenge by ________

A.   Reducing its size

B.   Immediately producing antigen-specific antibodies

C.   Forming of a large number of cells that are unlike the original B cell

D.   Producing progeny cells that include plasma cells and memory cells

20: Naturally acquired passive immunity can result from the _____.

A.   Injection of vaccine

B.   Ingestion of interferon

C.   Placental transfer of antibodies

D.   Bsorption of pathogens through mucous membranes

21: This medullary region of the lymph node contains primarily ________.

A.   Microphages

B.   Macrophages

C.   Tonsillar crypts

22: White blood cells and ____ carry out innate immune responses

A.   Defensive proteins

B.   Attecking proteins

C.   None

23: When an antigen is bound to a class i mhc molecule, it can stimulate a ________ cell.

A.   Helper T

B.   NK

C.   Plasma

D.   Cytotoxic T

24: When an antigen is bound to a class ii mhc protein, it can activate a ________ cell.

A.   CD4 T

B.   NK

C.   Cytotoxic T

D.   Suppressor T

E.   Plasma

25: A primary immune response is the ______.

A.   Coating the surface of microbes, making it easier for other defense cells to phagocytize them

B.   Immune response elicited by the first exposure of lymphocytes to a particular antigen

C.   The highest concentration of antibodies that occurs after the first exposure to antigen X

D.   Results in the production of short-lived effector cells via clonal selection

26: Antibodies are produced and secreted by ______

A.   Plasma cells

B.   T cells

C.   Bone marrow

D.   B cells

27: A characteristic symptom of necrotizing fasciitis is that the pain __________.

A.   An enzyme breaks the bacteria free from the phagosome

B.   Is disproportionate to the appearance of the infection

C.   Avoid eating raw fruits and vegetables

D.   Patients may be allergic to penicillins

28: Any substance that triggers an immune response in the body is called a(n) ________.

A.   Antigen

B.   Active immunity

C.   Antibody

D.   Passive immunity

29: Antigens bound to mhc ii activate __________.

A.   Helper B cells

B.   Helper T cells

C.   Cytokines

30: Antigens that depend on the function of t-helper cells are called __________ antigens.

A.   T-dependent

B.   T-independent antigens

C.   Both A & B

31: Antimicrobial peptides called ________ are secreted in sweat and damage bacteria and fungi.

A.   Antibodies

B.   Dermcidins

C.   TLRs

D.   Complement factors

32: ________ exists when the immune system does not respond to a particular antigen.

A.   Tolerance

B.   Memory

C.   None

33: ________ is the capacity to mount a secondary response to the same antigen.

A.   Primary response

B.   Memory

C.   Innate Immunity

D.   Affinity

34: Antibodies are __________ produced in response to an antigen.

A.   Immune system cells

B.   Glycoproteins

C.   Proteins

D.   Antigens

35: Autoimmune diseases are an example of a(n) ________ response by the immune system.

A.   Lack of

B.   Overactive

C.   Incorrect

D.   None of the answers are correct

36: Cd8 markers are to ________ t cells as cd4 markers are to ________ t cells.

A.   Cytoxic; helper

B.   Suppressor; cytoxic

C.   Plasma; NK

D.   Helper; suppressor

E.   NK; cytoxic

37: Cytotoxic t (tc) cells are like natural killer (nk) cells because they both __________.

A.   Secrete interferons

B.   Secrete granzymes and perforin

C.   Participate in the immune response

D.   Participate in innate immunity

E.   Secrete tumor necrosis factor (TNF

38: Fever is induced at the systemic level by ________, which is an endogenous pyrogen.

A.   CXCL8

B.   IL-12

C.   IL-6

D.   CCL2

39: Helper t-lymphocytes secrete ________ to stimulate the proliferation of b-lymphocytes.

A.   Cytokines

B.   Hepatitis

C.   Rabies

D.   Pregnancy

40: Igm is the first class of antibodies to be made during an immune response because ____.

A.   B cells producing IgM develop more rapidly than other types

B.   IgM is a multifunctional class of antibody

C.   The genes for IgM production are the most active ones in a B cell

D.   The gene for the mu Fc region is the first to be attached to the variable region gene

41: Il 2 is involved in __________ tc cells

A.   Self-stimulation of

B.   Clonal deletion of

C.   Antigen presentation to

D.   Clonal expansion of

42: In an antibody molecule, the __________ region mediates binding to host cells.

A.   Fc

B.   CD8

C.   Anergic

D.   None of these

43: Innate immunity and acquired immunity are both _____.

A.   Characteristics of all vertebrate animals

B.   Characteristics of all invertebrate animals

C.   Both A & B

D.   None of the above

44: Monoclonal antibodies are used for the diagnosis of all of the following except ________.

A.   Juvenile diabetes

B.   Hepatitis

C.   Rabies

D.   Pregnancy

45: Plasma cells ________.

A.   Are large so that they can envelope their prey by phagocytosis

B.   Have a great deal of rough endoplasmic reticulum to dispose of ingested pathogens

C.   Are small so that they slip between endothelial cells of capillaries to fight infection in the surrounding tissues

D.   Have a great deal of rough endoplasmic reticulum reflecting the fact that they secrete a tremendous amount of protein (antibody

46: Prostaglandins function to _________ during an immune response.

A.   Activate macrophage

B.   Activate complement

C.   Induce fever by raising the body's temperature

D.   Recruit phagocytic cells

47: T lymphocytes are to the _____ as b lymphocytes are to the _____.

A.   Thalamus; bone marrow

B.   Bone marrow; thymus

C.   Bone marrow; thalamus

D.   Thymus; bone marrow

48: The eyes and the respiratory tract are both protected against infections by _____.

A.   The mucous membranes that cover their surface

B.   The secretion of complement proteins

C.   The release of slightly acidic secretions

D.   The secretion of lysozyme onto their surface

E.   Interferons produced by immune cells

49: The helper t-cell clones stimulate antibody production by _____.

A.   B cells

B.   Complement cells

C.   Plasma cells

D.   T cells

50: The secondary response in humoral immunity occurs when memory cells bind to ______.

A.   Antigens

B.   Complement cells

C.   Plasma cells

D.   T cells